Inhibition of CYP11A1 and other steroidogenic enzymes with ketoconazole, but not inhibition of CYP11B by metyrapone 32,33, largely reversed RSL3 induced cell
Side effects Warnings Before taking Dosage Interactions FAQ What is ketoconazole? Ketoconazole is an antifungal medication that is used to treat certain infections caused
Originally developed as an antifungal agent, ketoconazole is
Therefore, the ketoconazole therapy was discontinued and the plasma transaminases returned to normal levels
Ketoconazole and metyrapone are most frequently used for this purpose, but chronic treatment with these drugs can be limited by side effects like hepatotoxicity (ketoconazole) and increased androgen and mineralocorticoid production (metyrapone)
Removal of the strong inhibitory feedback mechanism exerted by cortisol results in an Medical agents considered were ketoconazole, metyrapone, mitotane, cabergoline, pasireotide, and mifepristone
This agent further reduces serum cortisol, however, and may induce adrenal insufficiency
Its use is limited by hepatotoxicity that presents in 10-20% of the treated
Metyrapone is often a better choice in male patients with CD, owing to its androgenic effects (acne and
For example, Corcuff et al
Most importantly, the dose of mitotane required to treat Cushing’s disease is The ketoconazole was shift to metyrapone but afterwards ketoconazole was added again
5 months; UFC remained normal with mitotane monotherapy
Metyrapone exerts its effects through reversible inhibition of steroid 11β-hydroxylase, causing increased ACTH secretion, which in turn increases plasma 11-deoxycortisol levels [69]
The drugs available to date include metyrapone, ketoconazole, and mitotane
Among these agents, some have been used for decades based on observations from retrospective reports but have not been studied
These are not all of the side effects that may occur