Amlodipine metabolism and excretion

After intravenous administration, the percentages of the dosed radioactivity recovered in urine were 62% in humans, 45% in dogs, 38% in rats, and 25% in mice. Abstract By comparison with other calcium antagonist drugs, amlodipine has unique pharmacokinetic properties that are Amlodipine is extensively metabolized in the liver (but there is no significant presystemic or first-pass metabolism) and is slowly cleared with a terminal elimination half-life of 40 to 50 hr

2024-03-29
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  1. }, author={Henry L
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  4. Amlodipine is a low-clearance, dihydropyridine calcium antagonist
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  6. Metabolism
  7. Article
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